M. Gursel, I. Gursel, Development of CpG ODN Based Vaccine Adjuvant Formulations, Methods Mol Biol. 1404:289-98, 2016, (IF:1.29) PubMed-Logo

S. Fais, L. O’Driscoll, F.E. Borras, E. Buzas, G. Camussi, F. Cappello, J. Carvalho, A. Cordeiro da Silva, H. Del Portillo, S. El Andaloussi, T. Ficko Trček, R. Furlan, A. Hendrix, I. Gursel, V. Kralj-Iglic, B. Kaeffer, M. Kosanovic, M.E. Lekka, G. Lipps, M. Logozzi, A. Marcilla, M. Sammar, A. Llorente, I. Nazarenko, C. Oliveira, G. Pocsfalvi, L. Rajendran, G. Raposo, E. Rohde, P. Siljander, G. van Niel, M.H. Vasconcelos, M. Yáñez-Mó, M.L. Yliperttula, N. Zarovni, A.B. Zavec, B. Giebel, Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine, ACS Nano. 26;10(4):3886-99, 2016, (IF:12.881) PubMed-Logo

B. Gungor, E. Adiguzel, I. Gursel, B. Yilmaz, M. Gursel, Intestinal Microbiota in Patients with Spinal Cord Injury, PLoS One. 11;11(1):e0145878, 2016, (IF:3.234) PubMed-Logo


M. Yáñez-Mó, P.R. Siljander, Z. Andreu, A.B. Zavec, F.E. Borràs, E.I. Buzas, K. Buzas, E. Casal, F. Cappello, J. Carvalho, E. Colás, A. Cordeiro-da Silva, S. Fais, J.M. Falcon-Perez, I.M. Ghobrial, B. Giebel, M. Gimona, M. Graner, I. Gursel, M. Gursel, N.H. Heegaard, A. Hendrix, P. Kierulf, K. Kokubun, M. Kosanovic, V. Kralj-Iglic, E.M. Krämer-Albers, S. Laitinen, C. Lässer, T. Lener, E. Ligeti, A. Linē, G. Lipps, A. Llorente, J. Lötvall, M. Manček-Keber, A. Marcilla, M. Mittelbrunn, I. Nazarenko, E.N. Nolte-’t Hoen, T.A. Nyman, L. O’Driscoll, M. Olivan, C. Oliveira, É Pállinger, H.A. Del Portillo, J. Reventós, M. Rigau, E. Rohde, M. Sammar, F. Sánchez-Madrid, N. Santarém, K. Schallmoser, M.S. Ostenfeld, W. Stoorvogel, R. Stukelj, S.G. van der Grein, M.H. Vasconcelos, M.H. Wauben, O. De Wever, Biological properties of extracellular vesicles and their physiological functions, J Extracell Vesicles. 4:27066, 2016, (IF:-) PubMed-Logo

D. Bayik, I. Gursel, D.M. Klinman, Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides, Pharmacol Res. 2016 Jan, (IF: 2.92) PubMed-Logo

S. Yildiz, E. Alpdundar, B. Gungor, T. Kahraman, I. Gursel, M. Gursel, Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell-penetrating peptide or combined with CpG, Eur J Immunol. 45(4):1170-9, 2016,  (IF: 4.04) PubMed-Logo


B. Gungor, F.C. Yagci, G. Tincer, B. Bayyurt, E. Alpdundar, S. Yildiz, M. Ozcan, I. Gursel, M. Gursel, CpG Oligodeoxynucleotide/Cationic Peptide Nanorings induce IFNα Production from Plasmocytoid Dendritic Cells and Demonstrate Potent Vaccine Adjuvant Activity, Sci. Transl. Med. 6, 235ra61, 2014, (IF: 10.76) PubMed-Logo

B. Gungor, Y.C. Yagci, I. Gursel, M. Gursel, Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings, Oncoimmunology. 3;3(7), 2014, (IF:6.266) PubMed-Logo


M. Gursel, D.M. Klinman, I. Gursel, Plasmacytoid dendritic cell response to CpG ODN correlates with CXCL16 expression and is inhibited by ox-LDL, Mediators Inflamm. 2013:312590. doi: 10.1155/2013/312590. Epub 2013 Nov 4, (IF: 3.882) PubMed-Logo

C. Sackesen,  M. Akdis, O. Soyer, J. Zumkehr, B. Ruckert, O. KalaycI, S. S. Alkan, I. Gursel, C. A. Akdis, Suppression of B cell activation and IgE, IgA, IgG1 and IgG4 production by mammalian telomeric oligonucleotides , Allergy (2013 Mar 9. doi: 10.1111/all.12133. [Epub ahead of print]), (IF:6.271) PubMed-Logo

O. Osmanagaoglu, F. Kiran, F.C. Yagci, I. Gursel,  Immunomodulatory function and in vivo properties of Pediococcus pentosaceus OZF, apromising probiotic strain, 2012 Annals of Microbiology, vol. 63, no4, pp. 1311-1318, 2013, (IF:0.689) images


S. Okay , E. Ozcengiz, I. Gursel, G. Ozcengiz, Immunogenicity and protective efficacy of the recombinant Pasteurella lipoprotein E and outer membrane protein H from Pasteurella multocida A:3 in mice. Res Vet Sci., 93(3): 1261-1265, 2012, (IF:1.649) PubMed-Logo

G. Bayramoglu, I. Gursel, M. Yilmaz, M.Y. Arica, Immobilization of laccase on itaconic acid grafted and Cu(II) ion chelated chitosan membrane for bioremediation of hazardous materials, J.Chem.Technol. Biotechnol., 8(4):530–539, 2012, (IF: 2.168) wiley_logo


E.Birben, C. Saçkesen, S. Kazanı, G. Tinçer, C. Karaaslan, B. Durgunsu, I. Gursel, M. E. Wechsler, E. Israel, O. Kalaycı. The effects of an insertion in the 5′UTR of the AMCase on gene expression and pulmonary functions, Respir Med. 105(8):1160-69, 2011, (IF:2.475) PubMed-Logo

G. Tincer, S. Yerlikaya, F.C. Yagci, T. Kahraman, O.M. Atanur, O. Erbatur, I. Gursel., Immunostimulatory activity of polysaccharide-poly(I:C) nanoparticles. Biomaterials. 32(18): 4275-82, 2011, (IF:8.415) PubMed-Logo

E. Erikçi, M. Gursel, I. Gursel.,Differential immune activation following encapsulation of immunostimulatory CpG oligodeoxynucleotide in nanoliposomes. Biomaterials. Feb;32(6):1715-23, 2011 (IF:8.415) PubMed-Logo


F.C. Yagci, O. Aslan, M. Gursel, G. Tincer, Y. Ozdamar, K. Karatepe, K.C. Akcali, I.Gursel, Mammalian telomeric DNA suppresses endotoxin induced uveitis. J Biol Chem. 2010 Jul 14. [Epub ahead of print] 285(37):28806-28811, 2010, (IF:5.330) PubMed-Logo


G. Bayramoglu, I. Gursel, Y. Tunali, M. Y. Arica, Biosorption of phenol and 2-chlorophenol by Funalia trogii pellets, Biores.Technol. 100(10):2685-2691, 2009, (IF:4.980) PubMed-Logo


MK. Abak, O. Aktas, R. Mammadov, I. Gursel,  A. Dana, Parametrically coupled multiharmonic force imaging, Appl.Phys.Letts, 92(22): Article Number: 223113, 2008, (IF:3.840) LINK


S. Klaschik, I. Gursel, D.M. Klinman, CpG-mediated changes in gene expression in murine spleen cells identified by microarray analysis,  Mol. Immunol., 44(6):1095-1104, 2007, (IF:3.200) PubMed-Logo


M. Gürsel *, I. Gursel*, H.S. Mostowski, D.M. Klinman, CXCL16 influences the nature and specificity of CpG-induced immune activation, J. Immunol., 177(3):1575-1580, 2006 * equal contribution, (IF:5.788) PubMed-Logo


D.M. Klinman, I. Gursel, S. Klaschik, L. Dong, D. Currie, H. Shirota, Therapeutic potential of oligonucleotides expressing immunosuppressive TTAGGG motifs, Ann. N.Y. Acad. Sci. 1058, 87-95, 2005, (IF:3.155) PubMed-Logo

H. Shirota, I. Gursel, M. Gursel, D. M. Klinman, Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock, J. Immunol. 174(8):4579-4583, 2005, (IF:5.788) PubMed-Logo

H. Xie, I. Gursel, B. Ivins, D.O`Hagan, J. Ulmer, D.M. Klinman, CpG oligodeoxynucleotides adsorbed onto PLG microparticles improve the immunogenicity and efficacy of anthrax vaccine, Infect. Immun. 73(2):828-833, 2005, (IF:4.165) PubMed-Logo


D.M. Klinman, D. Currie, I. Gursel, D. Verthelyi, Use of CpG oligodeoxynucleotides as immune adjuvants, Immunol. Rev. 199:201-216, 2004, (IF:11.148) PubMed-Logo

K.J. Ishii, I. Gursel, M. Gursel, D. M. Klinman, Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides, Curr. Op. Mol. Ther. 6(2):166-174, 2004, (IF:3.680) PubMed-Logo

F. Takeshita, I. Gursel, K.J. Ishii, K. Suzuki, M. Gursel, D. M. Klinman, Signal transduction pathways mediated by the interaction of CpG DNA with toll-like receptor 9, Semin. Immunol. 16, 17-22, 2004, (IF:6.393) PubMed-Logo


K.J. Ishii, K. Kawakami, I. Gursel, B.H. Joshi, D.M. Klinman, R.K. Puri. Anti-tumor therapy with bacterial DNA and toxin:  complete regression of established tumor induced by liposomal CpG ODN plus IL-13 cytotoxin, Clin. Cancer Res. 9(17), 6516-6522, 2003, (IF:7.742) PubMed-Logo

D. M. Klinman, R.A. Zeuner, H. Yamada, M. Gursel, D. Currie, I. Gursel, Regulation of CpG-induced immune activation by suppressive oligodeoxynucleotides, Ann. N.Y. Acad. Sci. 1002, 112-123, 2003, (IF:3.155) PubMed-Logo

I. Gursel, M. Gursel, H. Yamada, F. Takeshita, K. J. Ishii, D. M. Klinman, Repetitive elements present in mammalian telomeres suppress CpG DNA induced immune activation, J. Immunol. 171:1393-1400, 2003 (this study was picked as the cover story: (IF:5.788) PubMed-Logo

A. Yagmurlu, M. Barlas, I. Gursel. I.H. Gokcora, Reduction of injury induced peritoneal adhesions by continuous release of streptokinase from a drug delivery system, Eur.Surg.Res. 35(1):46-49, 2003, (IF:0.932) PubMed-Logo


H. Yamada, I. Gursel, F. Takeshita, J. Conover, K. J. Ishii, M. Gursel, S. Takeshita, and D. M. Klinman, Effect of Suppressive DNA on CpG-Induced Immune Activation, J. Immunol.  169: 5590-5594, 2002, (IF:5.788) PubMed-Logo

R.A. Zeuner, K.J. Ishii, M. Lizak, I. Gursel, H. Yamada, D.M. Klinman, D. Verthelyi, Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides, Arthritis Rheum. 46(8) 2219-2224, 2002, (IF:7.866) wiley_logo

D.M. Klinman, F. Takeshita, I. Gursel, C. Leifer, K.J. Ishii, D. Verthelyi, M. Gursel , CpG DNA: recognition by and activation of monocytes, Microbes Infection, 4(9) 897-901, 2002, (IF:3.101) PubMed-Logo

K. J. Ishii, F. Takeshita, I. Gursel, M. Gursel, J. Conover, A. Nussenzweig, D. M. Klinman, Potential role of PI3 kinases, rather than DNA-PK, in CpG DNA induced immune activation, J. Exp. Med. 196(2):269-74, 2002, (IF:14.700) PubMed-Logo

M. Gursel, D. Verthelyi, I. Gursel, K.J. Ishii, D.M. Klinman, Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide, J. Leuko. Biol, 71(5):813-820, 2002, (IF:4.992) PubMed-Logo

HA Anderson, R. Englert, I. Gursel, E. Shacter, Oxidative stress inhibits the phagocytosis of apoptotic cells that have externalized phosphatidylserine Cell Death Differ. 9(6):616-625, 2002, (IF:8.849) PubMed-Logo

I. Gursel, M.F.Yagmurlu, F.Korkusuz, V. Hasirci, In vitro antibiotic release from poly(hydroxybutyrate-co-3-hydroxyvalerate) rods, J. Microencapsulation 19:(2)153 -164, 2002, (IF:1.553) PubMed-Logo

E. Gudemez, F. Eksioglu, P. Korkusuz, E. Asan, I. Gursel, V. Hasirci, Chondroitin sulphate coated hydroxyethyl methacrylate membrane prevents adhesion in full thickness tendon tears in rabbit, J. Hand Surg-Am Ed, 27A: 293-306, 2002, (IF:1.350) PubMed-Logo


F. Takeshita, C. Leifer, I. Gursel, K. J. Ishii, S. Takeshita, M. Gursel, D. M. Klinman, Role of Toll-like receptor-9 in CpG DNA induced activation of human cells. J. Immunol. 167(7):3555-3558, 2001, (IF:5.788) PubMed-Logo

I. Gursel, M. Gursel, K. J. Ishii, D.M. Klinman, Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides, J. Immunol.167(6):3324-3328, 2001, (IF:5.788) PubMed-Logo

F. Korkusuz, P. Korkusuz, F. Eksioglu, I. Gursel, V Hasirci, In vivo response to biodegradable antibiotic release systems, J. Biomed. Mater. Res. 55:217-228, 2001, (IF:2.625) PubMed-Logo

I. Gursel, F. Korkusuz, F. Turesin, N.G. Alaeddinoglu, V Hasirci, In vivo application of biodegradable controlled antibiotic release systems for the treatment of implant-related osteomyelitis, Biomaterials 22:(1) 73-80, 2001, (IF:8.404) PubMed-Logo

F. Turesin, I. Gursel, V. Hasirci, Biodegradable polyhydroxyalkanoate implants for osteomyelitis therapy: in vitro antibiotic release, J. Biomat. Sci-Polym Ed. 12:195-207, 2001, (IF:1.690) PubMed-Logo


D.M. Klinman, S. Kampstrup, D. Verthelyi, I. Gursel, K. J. Ishii, F. Takeshita, M. Gursel, Activation of the innate immune system by CpG oligodeoxynucleotides: immunoprotective activity and safety, Springer Semin. Immunopathol. 22(1-2): 173-183, 2000, (IF:4.170) PubMed-Logo

D.M. Klinman, K. J. Ishii, M. Gursel, I. Gursel, S. Takeshita and F. Takeshita, Immunotherapeutic applications of CpG containing oligodeoxynucleotides, Drug News and Perspectives 13(5),289-296, 2000, (IF:2.208) PubMed-Logo

F.Türesin, Z.Gümüşyazıcı, F.N.Kök, I.Gursel, N.G.Alaadinoğlu, V.Hasırcı, Biosynthesis of Polyhydroxybutyrate and its copolymers and Their use in controlled drug release. Tr. J. Med. Sci. 30:535-541, 2000, (IF:0.139) LINK

D. Sendil, I. Gursel, V.Hasirci, Preparation of PHBV foams and investigation of their potential for drug release, Tr. J. Med. Sci. 30: 9-14, 2000, (IF:0.139) LINK


M.F.Yagmurlu, F.Korkusuz, I. Gursel, P.Korkusuz, U.Ors, V.Hasirci, Sulbactam-cefoperazone polyhydroxybutyrate-co-hydroxyvalerate (PHBV) local antibiotic delivery system: In vivo effectivity and biocompatibility in the treatment of implant related experimental osteomyelitis, J. Biomed. Mater. Res. 46, 494-503, 1999, (IF:2.625) PubMed-Logo

D. Sendil, I. Gursel, D.L. Wise, and V. Hasirci, Antibiotic Release from biodegradable PHBV microparticles, J. Contr. Rel. 59,207-217, 1999, (IF:7.529) PubMed-Logo


I. Gursel, C. Balçık, Y. Arica, O. Akkuş, N. Akkaş, V. Hasirci, Synthesis and mechanical properties of interpenetrating networks of polyhydroxybutyrate-co-hydroxyvalerate and polyhydroxyethyl methacrylate, Biomaterials, 19(13):1137-1143, 1998 (IF:8.404) PubMed-Logo


I. Gursel, Y. Arica, V. Hasirci, Immobilization of glucose oxidase and urease, in hydrogel matrices, Turkish J. Chem. 21(4):387-393, 1997, (IF:0.943) LINK


G. Gregoriadis, I. Gursel, M. Gursel, B. Mc. Cormack, Liposomes as immunological adjuvants and vaccine carriers, J. Contr. Rel. 41:49-56, 1996 (IF:7.529)

I. Gursel, C. Balcik, Y. Arica, O. Akkus, V. Hasirci, and N. Akkas, Interpenetrating networks of polyhydroxybutyrate-co-hydroxyvalerate, and polyhydroxyethyl methacrylate: mechanical properties, Engineering Systems Design and Analysis, 5:107-111, 1996


I. Gursel, and V. Hasirci, Microcapsules of PHB and PHBV: morphology and release characteristics, J. Microencapsulation, 12(2):185-193, 1995, (IF:1.553)


I. Gursel, and V. Hasirci, Matrix entrapment of glucose oxidase by gamma-irradiation, Biomaterials, 13(3):150-155, 1992, (IF:8.404) PubMed-Logo