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Contact Info: |
Research Interests:
- Investigation of immunostimulatory effects of different liposomes coencapsulating Toll-like receptor (TLR) ligands such as CpG oligonucleotides (ligand of TLR9) and pI:C (ligands of TLR3) together with antigen and investigation of in vivo performance of liposomal vaccines in different diseases.
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Academic Degrees |
2011-2017 |
Ph.D. |
Molecular Biology and Genetics |
Bilkent University, Ankara, Turkey |
Supervisor: Prof. İhsan Gürsel |
2006-2009 (March) |
M.Sc. |
Biotechnology |
METU, Ankara, Turkey |
Supervisor: Prof. Vasıf Hasırcı |
2002-2006 |
B.S. |
Biology |
Hacettepe University, Ankara, Turkey |
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Publications |
S. Yildiz, E. Alpdundar, B. Gungor, T. Kahraman, B. Bayyurt, I. Gursel, M. Gursel (2015) Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell-penetrating peptide or combined with CpG. Eur J Immunol. [Epub ahead] |
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B Gungor, FC Yagci, G Tincer, B Bayyurt, E Alpdundar, S Yildiz, M Ozcan, I Gursel, M Gursel (2014) Production from Plasmocytoid Dendritic Cells and Demonstrate Potent Vaccine Adjuvant Activity. Sci Transl Med 6(235):235ra61. |
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B. Bayyurt, V. Hasirci (2012) The anti-proliferative effect of Celecoxib loaded pNIPAM nanoparticles. J Biomater Tis Eng, 2:3, 220-227(8). |
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A.B. Ertan, P. Yilgor, B. Bayyurt, A.C. Calikoglu, C. Kaspar, F.N. Kok, G.T. Kose, V. Hasirci (2011) Effect of double growth factor release on cartilage tissue engineering. J Tissue Eng Regen Med. 7(2):149-60. |
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Research Experiences |
2013-… |
Research Assistant |
Ministry of Science and Technology, SANTEZ project (1414 STZ.2012-1). Development of oligodeoxynucleotide based adjuvants for FMD vaccine formulation. Bilkent University, Department of Molecular Biology and Genetics, Turkey. |
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2006-2009 |
Research Asistant |
TUBITAK. Nanobiomat Project (TBAG, 105T508). Supervisor: Prof. Vasif Hasirci. Middle East Technical University (METU), Biotechnology Department, Turkey. |
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2006-2009 |
Research Asistant |
DPT (Turkish State Planning Organization) Use of pH and temperature responsive, intelligent nanobiomaterials in cartilage tissue engineering and investigation of cell adhesion process at nano-level. Supervisor: Prof. Vasif Hasirci. Middle East Technical University (METU), Biotechnology Department, Turkey. |
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2006-2009 |
Research Asistant |
Expertissues Network of Excellence (Noe), The European Union (EU) Sixth framework Programme (FP6). Novel therapeutic strategies for tissue engineering of bone and cartilage using second generation biomimetic scaffolds. Supervisor: Prof. Vasif Hasirci. Middle East Technical University (METU), Biotechnology Department, Turkey. |
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Scholarships and awards |
- Conference Bursary: by Turkish Society of Immunology for Molecular Immunology & Immunogenetics Congress, Antalya, Turkey, April 2014.
- Travel grant: by European Federation of Immunological Societies (EFIS) for 15th International Congress of Immunology, Milan, Italy, August 2013 .
- Project bursary, Ministry of Industry and Trade (SANTEZ grant, 1414 STZ.2012-1), “Development of Oligdeoxynucleotide Based Adjuvants for FMD Vaccine Formulation.”, Jan. 2013 (Duration: 24 months).
- Registration scholarship by the European Federation of Immunological Societies (EFIS). EFIS-EJI Course on Innate Immunity 2012: From Evolution to Revolution, Italy, Oct. 2012.
- Full scholarship including living and traveling expenses by Novartis Company. The Novartis International Biotechnology Leadership Camp (BioCamp), Switzerland, Aug. 2012.
- Registration and travel award by EMBO. EMBL Symposium: New Perspectives on Immunity to Infection, Germany, May 2012.
- Registration and accommodation awards by Turkish Society of Immunology. Molecular Immunology & Immunogenetics Congress (MIMIC2012), Turkey, Apr. 2012.
- Registration and accommodation awards by Turkish Society of Immunology. 21th National Immunology Congress, Turkey, Apr. 2011.
- Full scholarship, Graduate education, Bilkent University, Department of Molecular Biology and Genetics, Turkey, 2011-…
- M.Sc. scholarship stipent from TÜBİTAK (TBAG 105T508), 2007–2009.
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Conference Communications |
2013 |
B. Bayyurt, G. Gucluler, D. Bayik, E. Alpdundar, S. Yildiz, B.H. Horuluoglu, M. Ozcan, M. Gursel, I. Gursel, Extended anti-cancer immunity by liposomes coencapsulating nucleic acid TLR-ligands and antigen. 15th International Congress of Immunology, August 22-27, 2013. Milan, ITALY (Poster presentation). |
E. Alpdundar, S. Yildiz, B. Bayyurt, M. Ozcan, G. Gucluler, D. Bayik, B. Gungor, I. Gursel, M. Gursel, Commensal bacteria derived membrane vesicles suppress Th-1 dominated immune responses in vaccinated and tumor-bearing mice. 15th International Congress of Immunology, August 22-27, 2013. Milan, ITALY (Poster presentation). |
S. Yildiz, E. Alpdundar, B. Bayyurt, M. Ozcan, G. Gucluler, D. Bayik, , B. Gungor, I. Gursel, M. Gursel, Cyclic-di-GMP based immune stimulatory formulations as novel vaccine adjuvants and anti-cancer agents. 15th International Congress of Immunology, August 22-27, 2013. Milan, ITALY (Poster presentation). |
B. Bayyurt, G. Gucluler, D. Bayik, E. Alpdundar, S. Yildiz, M. Gursel, I. Gursel, The use of nano-liposomes encapsulating nucleic acid based TLR ligands together with antigen as a long-term effective cancer vaccine. 22nd National Immunology Congress, April 27–30, 2013. Cesme, TURKEY (Oral presentation). |
S. Yildiz, E. Alpdundar, B. Bayyurt, G. Gucluler, D. Bayik, M. Ozcan, B. Gungor, I. Gursel, M. Gursel, The efficiency of peptide complexes and vesicles containing C-di-GMP ligand as a vaccine adjuvant. 22nd National Immunology Congress, April 27–30, 2013. Cesme, TURKEY (Poster presentation). |
T. Kahraman, G. Gucluler, B. Bayyurt, M. Gursel, I. Gursel, The immune-adjuvant effect of CpG DNA loaded exosomes. 22nd National Immunology Congress, April 27–30, 2013. Cesme, TURKEY (Poster presentation). |
E. Alpdundar, S. Yildiz, B. Bayyurt, G. Gucluler, D. Bayik, M. Ozcan, B. Gungor, I. Gursel, M. Gursel, The immunomodulator effects of commensal bacteria derived membrane vesicles. 22nd National Immunology Congress, April 27–30, 2013. Cesme, TURKEY (Poster presentation). |
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2012 |
B. Bayyurt, I. Gursel, Immunostimulatory Effect of Liposome Coencapsulating Different TLR Ligands. The EFIS-EJI Course on Innate Immunity 2012: From Evolution to Revolution, October 31-November 4, 2012. Sorrento, Naples, ITALY (Poster presentation). |
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The Novartis International Biotechnology Leadership Camp (BioCamp), August 26-29, 2012. Basel, SWITZERLAND. |
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B. Bayyurt, I. Gursel, Potent Stimulation of the Innate Immune System by Nucleic Acid Based TLR Ligands Encapsulated in Nanoliposomes. 10th CIMT Annual Meeting, Towards Next-Generation Cancer Immunotherapy, May 23-25, 2012. Mainz, Germany (Poster presentation). |
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B. Bayyurt, E. Erikci, I. Gursel, Co-encapsulating nucleic acid based TLR ligands in nanoliposomes induce potent antiviral immune activation. The EMBO|EMBL Symposium: New Perspectives on Immunity to Infection, May 19-22, 2012. Heidelberg, Germany (Poster presentation). |
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T. Kahraman, B. Bayyurt, V. Ibrahimova, D. Tuncel, I. Gursel, CpG Loaded Fluorescent Polymeric Nanoparticles: a theranostic drug delivery system suitable for TLR based therapies. Molecular Immunology & Immunogenetics Congress, April 27-29, 2012. Antalya, Turkey (Poster presentation). |
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B. Bayyurt, I. Gursel, Nanoliposomes Encapsulating Nucleic Acid Based TLR Ligands Induce Inflammasome Mediated Potent Immune Activation. Molecular Immunology & Immunogenetics Congress, April 27-29, 2012. Antalya, Turkey (Poster presentation). |
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2011 |
Advances in Immunology and Cancer Biology Workshop, Istanbul, TURKEY, April 15–17, 2011. |
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B. Bayyurt, E. Erikci, I. Dereli, I. Gursel, Co-encapsulating pI:C and CpG ODNs in Nanoliposomes Induce Differential Immune Activation. 17th International Biomedical Science and Technology Symposium. November 23-25, 2011. Ankara, TURKEY (Poster presentation). |
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2008 |
Nanobiomaterials, Tissue Engineering and Nanobiotechnology Workshop. September, 1-2, 2008. METU, Ankara, TURKEY. |
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B. Bayyurt, V. Hasirci, Effect of Celecoxib-loaded Stimuli Responsive nanoparticles on Osteosarcoma cell Line. 14th International Biomedical Science and Technology Symposium. May 03-07, 2008. Mugla, TURKEY (Poster presentation). |
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2007 |
B. Bayyurt, V. Hasirci, Preparation and Characterization of Temperature-Sensitive Nanoparticles. 13th International Biomedical Science and Technology Symposium. August 26-28, 2007. Istanbul, TURKEY (Poster presentation). |
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A. Yilmazer, I. Altintas, B. Bayyurt, N. Ozturk, V. Hasirci, In Vitro Cancer Therapy Using Cationic Liposomes Containing Cisplatin. 13th International Biomedical Science and Technology Symposium. August 26-28, 2007. Istanbul, TURKEY (Poster presentation). |
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Expertissues Course on Surface and Biological Characterization of Materials Fundamentals of Theory and Practice (Workshop). April, 10-12, 2007. Trento University, Trento, ITALY. |