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Gizem Tinçer König

 
 GizemTincerKonig Contact Info: gizemtin@gmail.com
Research Interests:

  • Cooperation (in antagonistic and synergistic manners) between Toll-like receptor (TLR) ligands.
  • Mechanism of action of natural β-glucan polysaccharides.
  • Adjuvant effect of polysaccharide-nucleic acid based TLR ligand nanocomplexes.
  • Anti-cancer potential of polysaccharide-nucleic acid based TLR ligand nanocomplexes.
  • Immunomodulatory activity of novel nanoparticle forming CpG ODNs.
Academic Degrees
2007-2013 Ph.D. Molecular Biology and Genetics Bilkent University, Ankara, Turkey Supervisor: Prof. Dr. İhsan Gürsel
2005-2007 M.Sc. Molecular Biology and Genetics Bilkent University, Ankara, Turkey Supervisor: Prof. Dr. İhsan Gürsel
2001-2005 B.Sc. Biology Hacettepe University, Ankara, Turkey
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Publications
G.Tincer, K. Kobiyama, F.C. Yagci, C. Coban, K. J. Ishii, I. Gursel. Natural polysaccharide–nucleic acid TLR agonist nanocomplexes: Mechanism of action as immunotherapeutic agents. (In preparation), 2014.
 
B. Gungor, F.C. Yagci, G. Tincer, B. Bayyurt, E. Alpdundar, S. Yildiz, M. Ozcan, I. Gursel, M. Gursel. Production from plasmocytoid dendritic cells and demonstrate potent vaccine adjuvant activity. Sci. Transl. Med. 6, 235ra61 (2014).
 
E. Birben, C. Sackesen, S. Kazani, G. Tincer, C. Karaaslan, B. Durgunsu, I. Gursel, M.E. Wechsler, E. Israel, O. Kalayci. The effects of an insertion in the 5′UTR of the AMCase on gene expression and pulmonary functions. Respir. Med., 105(8):1160-9, 2011.
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G. Tincer, S. Yerlikaya, F.C. Yagci, T. Kahraman, O. M. Atanur, O. Erbatur, I. Gursel. Immunostimulatory activity of polysaccharide-poly(I:C) nanoparticles. Biomaterials, 32(18):4275-82, 2011.
 
I. Gursel, F.C. Yagci, G. Tincer, T. Kahraman, M. Gursel. Novel applications of DNA nanoparticles in nanomedicine and nanobiotechnology. Science and Technology Journal (by TÜBİTAK, Turkey), 520:44-48, 2011 (Article in Turkish).
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F.C. Yagci, O. Aslan, M. Gursel, G. Tincer, Y. Ozdamar , K. Karatepe, K.C. Akcali, I. Gursel., Mammalian telomeric DNA suppresses endotoxin-induced uveitis, J. Biol. Chem., 285(37):28806, 2010.
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Research Experiences
2014–… Project coordinator Ministry of Science and Technology (Teknogirişim Project# 0802.TGSD.2014). ”Development of biological adjuvants to enhance vaccine performance.”, NanoVacs Biotechnology Ltd.
 
2013–… Post doctoral researcher Supervisor: Prof. İhsan Gürsel, THORLAB, Bilkent University, Department of Molecular Biology and Genetics, Ankara, Turkey.
 
2009–2011 Researcher Ministry of Science and Technology, SANTEZ project (00448.STZ.2009-2). “Improving broiler chicken immune resistance by providing protection and reducing losses from stress and bacterial diseases with CpG DNA”, Bilkent University, Department of Molecular Biology and Genetics, Turkey.
 
Sept. 2010–Mar. 2011 Research Fellow Supervisors: Prof. Ken Ishii, Assoc. Prof. Cevayir Coban,
Osaka University, The WPI Immunology Frontier Research Center (IFReC), Japan.
 
2006–2009 Researcher TÜBİTAK project (SBAG-106S102). “Development of CpG ODN containing liposomal vaccines against pathogens”, Bilkent University, Department of Molecular Biology and Genetics, Turkey.
 
Scholarships and awards
  • Registration and accommodation awards by Turkish Society of Immunology. 2nd Molecular Immunology & Immunogenetics Congress (MIMIC2014), Turkey, Apr. 2014.
  • Travel award by European Federation of Immunological Societies (EFIS) 15th International Congress of Immunology, Milan, Aug. 2013.
  • Project bursary, TÜBİTAK project (SBAG-113S207). “TLR ligand and antigen loaded nanoliposomes as cancer vaccines.”, 2013– …
  • Registration and travel awards by Association for Cancer Immunotherapy. 10th CIMT Annual Meeting. Germany, May 2012.
  • Registration and accommodation awards by Turkish Society of Immunology. Molecular Immunology & Immunogenetics Congress (MIMIC2012), Turkey, Apr. 2012.
  • Best poster award, “Polysaccharide-TLR agonist nanocomplexes: Mechanism of action as immune adjuvants”, 17th International Symposium on Biomedical Science and Technology, Turkey, Nov. 2011.
  • Registration and accommodation awards by Turkish Society of Immunology. 21th National Immunology Congress, Turkey, Apr. 2011.
  • Research fellow, IFReC Kishimoto Foundation Fellowship, Osaka University, Japan, Sept. 2010–Mar. 2011.
  • Travel award by European Federation of Immunological Societies (EFIS) 14th International Congress of Immunology, Japan, Aug. 2010.
  • Project bursary, Ministry of Industry and Trade (SANTEZ grant, 00448.STZ.2009-2), “Improving broiler chicken immune resistance by providing protection and reducing losses from stress and bacterial diseases with CpG DNA.”, 2009–2011.
  • Project bursary, TÜBİTAK project (SBAG-106S102). “Development of CpG ODN containing liposomal vaccines against pathogens.”, 2006–2009.
  • Travel and accommodation awards by Turkish National Society of Allergy and Clinical Immunology. World Immune Regulation Meeting-II, Switzerland, Mar. 2007.
  • Full scholarship, Graduate education, Bilkent University, Department of Molecular Biology and Genetics, Ankara, Turkey, 2005–2013.
Conference Communications
 
  • G. Tincer, K. Almacioglu, F.C. Yagci, F. Kiran, I. Gursel. Exopolysaccharides from commensal bacteria alter TLR mediated Th1 immunity. 2nd International Molecular Immunology & Immunogenetics Congress (MIMIC II), Antalya, Turkey, 27–30 April 2014.
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  • G. Tincer, C. Coban, K. Ishii, I. Gursel. Polysaccharide nanocomplexes harboring Split Vaccine and TLR ligands are potent vaccine carriers against influenza. 15th International Congress of Immunology, Milan, Italy, 22–27 August 2013. (Poster presentation).
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  • G. Tincer, C. Coban, K. Ishii, I. Gursel. Immunotherapeutic applications of polysaccharide-TLR ligand nanocomplexes. 22nd National Immunology Congress, Cesme, Turkey, 27–30 April 2013. (Oral presentation, Turkish).
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  • G. Tincer, K. Karatepe, C. Coban, K. Ishii, M. Gursel, I. Gursel. Potential antitumor immunotherapeutic candidates: CpG ODN and PS nanocomplexes. 10th CIMT Annual Meeting, Mainz, Germany, 23–25 May 2012. (Poster presentation).
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  • G. Tincer, K. Karatepe, C. Coban, K. Ishii, M. Gursel, I. Gursel. CpG ODN nanoparticles and polysaccharide nanocomplexes: Improved antitumor action. Molecular Immunology & Immunogenetics Congress (MIMIC2012), Antalya, Turkey, 27–29 April 2012. (Poster presentation).
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  • G. Tincer, M. Sahin, C. Coban, K. Ishii, M. Gursel, I. Gursel. Polysaccharide-TLR agonist nanocomplexes: Mechanism of action as immune adjuvants. 17th International Symposium on Biomedical Science and Technology, Ankara, Turkey, 23–25 November 2011. (Poster presentation).
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  • B. Gungor, F.C. Yagci, G. Tincer, E. Alpdundar, S. Yildiz, I. Gursel, M. Gursel. Determination of immune stimulatory properties of synthetic CpG ODN/cationic peptide complexes. 17th International Symposium on Biomedical Science and Technology, Ankara, Turkey, 23–25 November 2011. (Poster presentation).
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  • G. Tincer, C. Coban, K. Ishii, I. Gursel. Improving immune response by natural polysaccharide-TLR ligand nanoparticles. Advances in Immunology and Cancer Biology Workshop, Istanbul, Turkey, 15–17 April 2011. (Poster presentation).
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  • G. Tincer, C. Coban, K. Ishii, I. Gursel.Synergistic effects of nucleic acid based TLR ligands complexed with polysaccharide nanoparticles on immune system. 21st National Immunology Congress, Marmaris, Turkey, 6–9 April 2011. (Oral presentation, Turkish).
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  • G. Tincer, C. Coban, K.J. Ishii, I. Gursel. Immunostimulatory Activity of Nucleic Acid Based TLR Ligands Complexed with Polysaccharide Nanoparticles. Towards Comprehensive Understanding of Immune Dynamism (TCUID 2011), Osaka, Japan, 1–2 March 2011. (Poster presentation).
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  • G. Tincer, S. Yerlikaya, I. Gursel. β-Glucans effectively binds TLR3, 7, and 9 ligands and improves innate immune response. 14th  International Congress of Immunology, Kobe, Japan, 22–27 August 2010. (Poster presentation).
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  • G. Tincer, O.M. Atanur, T. Balın, O. Erbatur, I. Gursel. Delivery of TLR ligands with polysaccharide nanocomplexes enhances immune activation. 5th National Nanoscience and Nanotechnology Conference, Eskişehir, Turkey, 8–12 June 2009. (Oral presentation).
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  • I. Gursel, F.C. Yagci, G. Tincer, M. Gursel. DNA Nanoparticles: Novel immunomodulatory adjuvants for immunotherapy. World Immune Regulation Meeting-II, Davos, Switzerland, 17–20 March 2008. (Poster presentation).
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  • G. Tincer, S. Yerlikaya, O.M. Atanur, T. Balın, O. Erbatur, I. Gursel. Immunomodulatory activity of polysaccharides extracted from Ganoderma and Shiitake mushrooms. 13th Biomedical Science and Technology Symposium, İstanbul, Turkey, 26–28 August 2007. (Poster presentation).
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  • G. Tincer, I. Gursel. Contrasting and synergistic immune responses mediated by nanoparticulate TLR ligands. 13th Biomedical Science and Technology Symposium, İstanbul, Turkey, 26–28 August 2007. (Poster presentation).
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  • G. Tincer, R. Mammadov, I. Gursel. Efforts to delineate contrasting and synergistic interaction of TLR ligands leading to a robust immune response. 1st Congress of the Society of Innate Immunity, Ankara, Turkey, 13–16 May 2007. (Oral presentation).