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Gözde Güçlüler

 
 GozdeGucluler Contact Info: gozdegucluler@gmail.com
Research Interests:

  • Application of extracellular vesicles to enhance the effect of immunostimulatory/immunsuppressive molecule on cancer and anti-inflammatory diseases.
Academic Degrees
2010-… Ph.D. Molecular Biology and Genetics Bilkent University, Ankara, Turkey Supervisor: Prof. Dr. İhsan Gürsel
2006-2010 B.Sc. Molecular Biology and Genetics Izmir Institute of Technology, Izmir, Turkey
Publications
Gucluler G, Piskin, O. Baran Y. The roles of antiapoptotic sphingosine kinase-1 and glucosylceramide genes in drug induced cell death of MCF-7 breast cancer cells. J BUON, 2011, 16(4): 646-51
Gucluler G, Baran Y. Docetaxel Enhances The Cytotoxic Effects Of Imatinib On Philadelphia Positive Human Chronic Myeloid Leukemia Cells. Hematology, 2009, 14(3): 139-144
Research Experiences
October 2010- . . PhD Student Supervisor: Prof. İhsan Gürsel, THORLAB, Bilkent University, Department of Molecular Biology and Genetics, Ankara, Turkey.
Sept. 2007–Aug. 2010 Special Project Student Supervisor: Assoc. Prof. Yusuf Baran, Izmir Institute of Technology, Department of Molecular Biology and Genetics, Cancer Genetics and Molecular Hematology Research Laboratory,
 
31 July – 25 Sept. 2009 Amgen Scholar Supervisor: Dr. Philipp Korber ,Ludwig-Maximilians-Universitat-München, Amgen Scholars Program 2009, Nucleosome Positioning and Remodeling in Yeast Laboratory
 
Scholarships and awards
  • Registration and accommodation awards by Turkish Society of Immunology. 2nd Molecular Immunology & Immunogenetics Congress (MIMIC2014), Turkey, Apr. 2014.
  • The Best Podium Presentation Award, International Liposome Society, ILS Liposome Advances Conference, London, United Kingdom, December 2014
  • Travel Award, Turkish Society of Immunology, 15th International Congress of Immunology,  Milan, Italy, August 2013
    • EFIS Travel Award, 15th International Congress of Immunology, Milan, Italy, August 2013
    • Travel Award, Amgen Scholars Alumni Support Scheme, 15th International Congress of Immunology, Milan, Italy, August 2013
    • Project bursary, Ministry of Industry and Trade (SANTEZ grant, 1414 STZ.2012-1), “Development of Oligdeoxynucleotide Based Adjuvants for FMD Vaccine Formulation.”, Jan. 2013 (Duration: 24 months)
    • Registration scholarship by the European Federation of Immunological Societies (EFIS). EFIS-EJI Course on Innate Immunity 2012: From Evolution to Revolution, Sorrento, Naples, Italy, Oct. 2012
    • Registration and Travel Award by EMBO (EMBL Symposium: New Perspectives on Immunity to Infection, Heidelberg, Germany, May 2012
    • Best Poster Award by Turkish Society of Immunology (G. Gucluler, T. Kahraman, I. Gursel. CpG ODN Loaded Exosome Nanovesicles: Enhanced Immunostımulatory Activity. Molecular Immunology&Immunogenetics Congress, Antalya, Turkey, April 2012).
    • Registration and accommodation awards by Turkish Society of Immunology. (Molecular Immunology&Immunogenetics Congress, Antalya, Turkey, April 2012).
    • Registration and accommodation awards by Turkish Society of Immunology. (21th National Immunology Congress, Marmaris, Turkey, April 2011).
      • Full scholarship, Graduate education, Bilkent University, Molecular Biology and Genetics Department (2010 – …).
    • “Amgen Scholar 2009” Award by AMGEN (Ludwig-Maximilians-Universitat München, Germany, July-September 2009)
Conference Communications
  • G. Gucluler, M. Sahin, T. Kahraman, A. Gursel, I. Gursel. Enhanced Immunostimulatory Properties of Extracellular Vesicles Horboring Different TLR Ligands. 2nd International Molecular Immunology & Immunogenetics Congress (MIMIC II), Antalya, Turkey, 27–30 April 2014. (Oral Presentation, English)
 
  • G. Gucluler, T. Kahraman, D. Bayik,  B.H. Horuluoglu, A. Gursel, I. Gursel. CpG ODN Loaded Extracellular Nanovesicles: Enhanced Immunotherapeutic Activity. ILS Liposome Advances Conference, London, United Kingdom, December 2013. (Oral Presentation, English)
 
  • G. Gucluler, T. Kahraman, D. Bayik, A. Gursel, M. Gursel, I. Gursel. D type CpG oligonucleotide loaded EG7 exosomes act as strong vaccine adjuvant and anti-cancer agent. 15th International Congress of Immunology,  Milan, Italy, August 2013. (Poster presentation).
 
  • T. Kahraman, G. Gucluler, D. Bayik, A, Gursel, I. Gursel. EXOLIGOS: a CpG oligonucleotide loaded exosome nanovesicle delivery platform suitable for effective immune modulation. 15th International Congress of Immunology,  Milan, Italy, August 2013. (Poster presentation).
 
  • S. Yildiz, E. Alpdundar, B. Bayyurt, M. Ozcan, G. Gucluler, D. Bayik, B. Gungor, I. Gursel, M. Gursel. Cyclic-di-GMP based immune stimulatory formulations as novel vaccine adjuvants and anti-cancer agents. 15th International Congress of Immunology,  Milan, Italy, August 2013 (Poster presentation).
 
  • E. Alpdundar, S. Yildiz, B. Bayyurt, M. Ozcan, G. Gucluler, D. Bayik, B. Gungor, I. Gursel, M. Gursel. Commensal bacteria-derived membrane vesicles suppress Th-1 dominated immune responses in vaccinated and tumor-bearing mice. 15th International Congress of Immunology,  Milan, Italy, August 2013 (Poster presentation).
 
  • G. Gucluler, T. Kahraman, D. Bayik, A. Gursel, M. Gursel, I. Gursel. D type CpG oligonucleotide loaded EG7 exosomes act as strong vaccine adjuvant and anti-cancer agent. 22th Turkish Congress of Immunology,  Cesme, Izmir, Turkey, April 2013 (Poster presentation).
 
  • G. Gucluler, T. Kahraman, I. Gursel. ODN-loaded exosome nanovesicles: A novel anticancer and vaccine delivery platform. Innate Immunity 2012:from Evolution to Revolution, Sorrento, Italy, November 2012. (Poster Presentation).
 
  • F. C. Yagci, G. Gucluler, F. Kiran, I. Gursel. Bacteriocin DNA nanocomplexes as immunotherapeutic carriers. 10th Annual Meeting of CIMT, Mainz, Germany, May 2012 (Poster presentation).
  • T. Kahraman, G. Gucluler, I. Gursel. A novel ODN delivery platform: CpG-ODN-loaded exosome nanovesicles. 10th Annual Meeting of CIMT, Mainz, Germany, May 2012 (Poster presentation).
  • G. Gucluler, T. Kahraman, I. Gursel. Immunostimulatory activity of CpG-ODN is enhanced via encapsulation into nanovesicles. New Perspective on Immunity to Infection. Heidelberg, Germany, May 2012 (Poster presentation).
  • G. Gucluler, T. Kahraman, I. Gursel. CpG ODN Loaded Exosome Nanovesicles: Enhanced Immunostımulatory Activity.  Molecular Immunology&Immunogenetics Congress, Antalya, Turkey, April 2012 (Poster presentation).
    • T. Kahraman, G. Gucluler, E. Alpdundar, M. Gursel, I. Gursel. Encapsulating CpG-ODNs into nanovesicles enhances their immunostimulatory action.  BIOMED, Ankara, Turkey, November, 2011 (Poster presentation).
    • T. Kahraman, G. Gucluler, M. Gursel, C. Ozen, I. Gursel. Transfer of CpG oligos to cells via exosome. 21th Turkish Congress of Immunology, Marmaris, Turkey, April, 2011 (Poster presentation).