Banu Bayyurt

 
 BanuBayyurt      Contact Info: banu.bayyurt@bilkent.edu.tr
    Research Interests:

  • Investigation of immunostimulatory effects of different liposomes coencapsulating Toll-like receptor (TLR) ligands such as CpG oligonucleotides (ligand of TLR9) and pI:C (ligands of TLR3) together with antigen and investigation of in vivo performance of liposomal vaccines in different diseases.

 

Academic Degrees
2011-… Ph.D. Molecular Biology and Genetics Bilkent University, Ankara, Turkey Supervisor: Prof. İhsan Gürsel
2006-2009 (March) M.Sc. Biotechnology METU, Ankara, Turkey Supervisor: Prof. Vasıf Hasırcı
2002-2006 B.S. Biology Hacettepe University, Ankara, Turkey
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Publications
S. Yildiz, E. Alpdundar, B. Gungor, T. Kahraman, B. Bayyurt, I. Gursel, M. Gursel (2015) Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell-penetrating peptide or combined with CpG. Eur J Immunol. [Epub ahead]
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B Gungor, FC Yagci, G Tincer, B Bayyurt, E Alpdundar, S Yildiz, M Ozcan, I Gursel, M Gursel (2014) Production from Plasmocytoid Dendritic Cells and Demonstrate Potent Vaccine Adjuvant Activity. Sci Transl Med 6(235):235ra61.
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B. Bayyurt, V. Hasirci (2012) The anti-proliferative effect of Celecoxib loaded pNIPAM nanoparticles. J Biomater Tis Eng, 2:3, 220-227(8).
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A.B. Ertan, P. Yilgor, B. Bayyurt, A.C. Calikoglu, C. Kaspar, F.N. Kok, G.T. Kose, V. Hasirci (2011) Effect of double growth factor release on cartilage tissue engineering. J Tissue Eng Regen Med. 7(2):149-60.
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Research Experiences
2013-… Research Assistant Ministry of Science and Technology, SANTEZ project (1414 STZ.2012-1). Development of oligodeoxynucleotide based adjuvants for FMD vaccine formulation. Bilkent University, Department of Molecular Biology and Genetics, Turkey.
 
2006-2009 Research Asistant TUBITAK. Nanobiomat Project (TBAG, 105T508). Supervisor: Prof. Vasif Hasirci. Middle East Technical University (METU), Biotechnology Department, Turkey.
 
2006-2009 Research Asistant DPT (Turkish State Planning Organization) Use of pH and temperature responsive, intelligent nanobiomaterials in cartilage tissue engineering and investigation of cell adhesion process at nano-level. Supervisor: Prof. Vasif Hasirci. Middle East Technical University (METU), Biotechnology Department, Turkey.
 
2006-2009 Research Asistant Expertissues Network of Excellence (Noe), The European Union (EU) Sixth framework Programme (FP6). Novel therapeutic strategies for tissue engineering of bone and cartilage using second generation biomimetic scaffolds. Supervisor: Prof. Vasif Hasirci. Middle East Technical University (METU), Biotechnology Department, Turkey.
 
Scholarships and awards
  • Conference Bursary: by Turkish Society of Immunology for Molecular Immunology & Immunogenetics Congress, Antalya, Turkey, April 2014.
  • Travel grant: by European Federation of Immunological Societies (EFIS) for 15th International Congress of Immunology, Milan, Italy, August 2013 .
  • Project bursary, Ministry of Industry and Trade (SANTEZ grant, 1414 STZ.2012-1), “Development of Oligdeoxynucleotide Based Adjuvants for FMD Vaccine Formulation.”, Jan. 2013 (Duration: 24 months).
  • Registration scholarship by the European Federation of Immunological Societies (EFIS). EFIS-EJI Course on Innate Immunity 2012: From Evolution to Revolution, Italy, Oct. 2012.
  • Full scholarship including living and traveling expenses by Novartis Company. The Novartis International Biotechnology Leadership Camp (BioCamp), Switzerland, Aug. 2012.
  • Registration and travel award by EMBO. EMBL Symposium: New Perspectives on Immunity to Infection, Germany, May 2012.
  • Registration and accommodation awards by Turkish Society of Immunology. Molecular Immunology & Immunogenetics Congress (MIMIC2012), Turkey, Apr. 2012.
  • Registration and accommodation awards by Turkish Society of Immunology. 21th National Immunology Congress, Turkey, Apr. 2011.
  • Full scholarship, Graduate education, Bilkent University, Department of Molecular Biology and Genetics, Turkey, 2011-…
  • M.Sc. scholarship stipent from TÜBİTAK (TBAG 105T508), 2007–2009.
Conference Communications
2013 B. Bayyurt, G. Gucluler, D. Bayik, E. Alpdundar, S. Yildiz, B.H. Horuluoglu, M. Ozcan, M. Gursel, I. Gursel, Extended anti-cancer immunity by liposomes coencapsulating nucleic acid TLR-ligands and antigen. 15th International Congress of Immunology, August 22-27, 2013. Milan, ITALY (Poster presentation).
E. Alpdundar, S. Yildiz, B. Bayyurt, M. Ozcan, G. Gucluler, D. Bayik, B. Gungor, I. Gursel, M. Gursel, Commensal bacteria derived membrane vesicles suppress Th-1 dominated immune responses in vaccinated and tumor-bearing mice. 15th International Congress of Immunology, August 22-27, 2013. Milan, ITALY (Poster presentation).
S. Yildiz, E. Alpdundar, B. Bayyurt, M. Ozcan, G. Gucluler, D. Bayik, , B. Gungor, I. Gursel, M. Gursel, Cyclic-di-GMP based immune stimulatory formulations as novel vaccine adjuvants and anti-cancer agents. 15th International Congress of Immunology, August 22-27, 2013. Milan, ITALY (Poster presentation).
B. Bayyurt, G. Gucluler, D. Bayik, E. Alpdundar, S. Yildiz, M. Gursel, I. Gursel, The use of  nano-liposomes encapsulating nucleic acid based TLR ligands together with antigen as a long-term  effective cancer vaccine. 22nd National Immunology Congress, April 27–30, 2013. Cesme, TURKEY (Oral presentation).
S. Yildiz, E. Alpdundar, B. Bayyurt, G. Gucluler, D. Bayik, M. Ozcan, B. Gungor, I. Gursel, M. Gursel, The efficiency of peptide complexes and vesicles containing C-di-GMP ligand as a vaccine adjuvant. 22nd National Immunology Congress, April 27–30, 2013. Cesme, TURKEY (Poster presentation).
T. Kahraman, G. Gucluler, B. Bayyurt, M. Gursel, I. Gursel, The immune-adjuvant effect of CpG DNA loaded exosomes. 22nd National Immunology Congress, April 27–30, 2013. Cesme, TURKEY (Poster presentation).
E. Alpdundar, S. Yildiz, B. Bayyurt, G. Gucluler, D. Bayik, M. Ozcan, B. Gungor, I. Gursel, M. Gursel, The immunomodulator effects of commensal bacteria derived membrane vesicles. 22nd National Immunology Congress, April 27–30, 2013. Cesme, TURKEY (Poster presentation).
2012 B. Bayyurt, I. Gursel, Immunostimulatory Effect of Liposome Coencapsulating Different TLR Ligands. The EFIS-EJI Course on Innate Immunity 2012: From Evolution to Revolution, October 31-November 4, 2012. Sorrento, Naples, ITALY (Poster presentation).
  The Novartis International Biotechnology Leadership Camp (BioCamp), August 26-29, 2012. Basel, SWITZERLAND.
  B. Bayyurt, I. Gursel, Potent Stimulation of the Innate Immune System by Nucleic Acid Based TLR Ligands Encapsulated in Nanoliposomes. 10th CIMT Annual Meeting, Towards Next-Generation Cancer Immunotherapy, May 23-25, 2012. Mainz, Germany (Poster presentation).
  B. Bayyurt, E. Erikci, I. Gursel, Co-encapsulating nucleic acid based TLR ligands in nanoliposomes induce potent antiviral immune activation. The EMBO|EMBL Symposium: New Perspectives on Immunity to Infection, May 19-22, 2012. Heidelberg, Germany (Poster presentation).
  T. Kahraman, B. Bayyurt, V. Ibrahimova, D. Tuncel, I. Gursel, CpG Loaded Fluorescent Polymeric Nanoparticles: a theranostic drug delivery system suitable for TLR based therapies. Molecular Immunology & Immunogenetics Congress, April 27-29, 2012. Antalya, Turkey (Poster presentation).
  B. Bayyurt, I. Gursel, Nanoliposomes Encapsulating Nucleic Acid Based TLR Ligands Induce Inflammasome Mediated Potent Immune Activation. Molecular Immunology & Immunogenetics Congress, April 27-29, 2012. Antalya, Turkey (Poster presentation).
 
2011 Advances in Immunology and Cancer Biology Workshop, Istanbul, TURKEY, April 15–17, 2011.
  B. Bayyurt, E. Erikci, I. Dereli, I. Gursel, Co-encapsulating pI:C and CpG ODNs in Nanoliposomes Induce Differential Immune Activation. 17th International Biomedical Science and Technology Symposium. November 23-25, 2011. Ankara, TURKEY (Poster presentation).
 
2008 Nanobiomaterials, Tissue Engineering and Nanobiotechnology Workshop. September, 1-2, 2008. METU, Ankara, TURKEY.
  B. Bayyurt, V. Hasirci, Effect of Celecoxib-loaded Stimuli Responsive nanoparticles on Osteosarcoma cell Line. 14th International Biomedical Science and Technology Symposium. May 03-07, 2008. Mugla, TURKEY (Poster presentation).
 
2007 B. Bayyurt, V. Hasirci, Preparation and Characterization of Temperature-Sensitive Nanoparticles. 13th International Biomedical Science and Technology Symposium. August 26-28, 2007. Istanbul, TURKEY (Poster presentation).
  A. Yilmazer, I. Altintas, B. Bayyurt, N. Ozturk, V. Hasirci, In Vitro Cancer Therapy Using Cationic Liposomes Containing Cisplatin. 13th International Biomedical Science and Technology Symposium. August 26-28, 2007. Istanbul, TURKEY (Poster presentation).
  Expertissues Course on Surface and Biological Characterization of Materials Fundamentals of Theory and Practice (Workshop). April, 10-12, 2007. Trento University, Trento, ITALY.